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Buy Cambridge IGF-1 LR3 in Dubai UAE Human IGF-1 LR3, insulin-like growth factor long arginine 3, protein is a synthetic form of IGF-1 with an N-terminal protein extension that improves potency and metabolic stability. IGF-1 LR3 is often used in the maintenance of human pluripotent stem cells. Highly pure and bioactive 9 kDa IGR-1 LR3 protein monomer, animal-free (AF) and carrier-protein free (CF). IGF-1 LR3 activity is determined using the Promega serum response element luciferase reporter assay (*) in transfected MCF-7 cells. EC50 = 12.0 ng/ml (1.3 nM). Buy Cambridge IGF-1 LR3 in Dubai UAE. Cells are treated in triplicate with a serial dilution of IGF-1 LR3 for 4 hours. Firefly luciferase activity is measured and normalized to the control Renilla luciferase activity. Data from Qk041 lot #104315. IGF-1 LR3 migrates as a single band at 10 kDa in non-reducing (NR) conditions and upon reduction (R).  No contaminating protein bands are visible. Buy Cambridge IGF-1 LR3 in Dubai UAE. Purified recombinant protein (3 µg) was resolved using 18% w/v SDS-PAGE in reduced ( β-mercaptothanol, R) and non-reduced (NR) conditions and stained with Coomassie Brilliant Blue R250.  Data from Qk041 batch #104315. Buy Cambridge IGF-1 LR3 in Dubai UAE. How does Cambridge IGF-1 LR3 work? Cambridge IGF-1 LR3 is a synthetic, lengthened analogue of human insulin-like growth factor-1 (IGF-1) designed to mimic and enhance the natural effects of IGF-1 in the body. It differs from native IGF-1 by having an arginine substitution at position 3 and an additional 13 amino acids at its N-terminus, which gives it a longer half-life (about 20-30 hours) and significantly reduces its binding to IGF-binding proteins (IGFBPs). This results in greater potency and prolonged activity compared to regular IGF-1. Buy Cambridge IGF-1 LR3 in Dubai UAE. IGF-1 LR3 binds to the IGF-1 receptor (IGF1R) on muscle and other cells, activating intracellular signaling pathways such as the PI3K/Akt and RAS/MAPK pathways. These pathways promote cell proliferation, differentiation, protein synthesis, and inhibit apoptosis, leading to increased muscle growth, enhanced fat metabolism, and improved tissue repair. In muscle tissue, it also increases insulin sensitivity, facilitating glucose uptake and reducing fat storage. Because of its enhanced stability and potency, less IGF-1 LR3 is needed to achieve effects similar to or greater than native IGF-1. It is commonly used in research to study muscle growth, fat metabolism, and regenerative processes. Buy Cambridge IGF-1 LR3 in Dubai UAE. In summary, Cambridge IGF-1 LR3 works by: Binding and activating IGF-1 receptors with higher potency due to reduced IGFBP binding. Stimulating muscle cell growth, repair, and protein synthesis via key signaling pathways. Enhancing fat metabolism and insulin sensitivity Providing prolonged biological activity thanks to its structural modifications. Buy Cambridge IGF-1 LR3 in Dubai UAE. What are the main benefits of using Cambridge IGF-1 LR3? The main benefits of using Cambridge IGF-1 LR3 include: Enhanced Muscle Growth and Recovery: IGF-1 LR3 stimulates muscle protein synthesis and satellite cell proliferation, promoting lean muscle mass gain and faster repair of muscle tissue after workouts, reducing recovery time. Buy Cambridge IGF-1 LR3 in Dubai UAE. Fat Loss and Improved Body Composition: It boosts fat metabolism (lipolysis) while preserving muscle mass, helping reduce body fat percentage and achieve a leaner physique. Buy Cambridge IGF-1 LR3 in Dubai UAE. Increased Energy and Athletic Performance: By optimizing glucose uptake and energy use, IGF-1 LR3 enhances stamina, endurance, and strength, supporting more intense and frequent training. 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